{"title":"Xenogreft","description":"","products":[{"product_id":"ibi-sa-smartbone-bone-regeneration-bone-graft-2gr","title":"SmartBone Bone Regeneration - Bone Graft 2gr","description":"\u003cp\u003e\u003cstrong\u003eSmartBone Bone Regeneration - Bone Graft 2gr\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA Bone graft born from Advanced Tissue Engineering Technology\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are produced by combining natural mineral bone structures with bioresorbable polymers and collagen fragments. This new concept of biomaterial assembly allows the patient’s cells to grow quickly and efficiently into the bone substitute while the biopolymers degrade, providing perfect integration and osteogenesis. Moreover, thanks to this technology our graft mimics the human bone, it is mechanically strong and resistant to shaping, screws and surgical fixation maneuvers.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are exactly the same products with just different brand names or different indications of use.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eBOVINE BONE MATRIX\u003cbr data-mce-fragment=\"1\"\u003ehas a chemical structure and a morphology that resemble the human bone\u003cbr data-mce-fragment=\"1\"\u003eis rigid, but not elastic, and thus too fragile (since the mineral matrix loses its biomechanical properties without proteins lost during the cleaning processes)\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eBIODEGRADABLE POLYMERS\u003cbr data-mce-fragment=\"1\"\u003eAllow to have:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003ehigh loading resistance\u003cbr data-mce-fragment=\"1\"\u003ehigh volumetric stability (\u0026gt;95%); the polymers protect the bone from early resorption\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eCOLLAGEN FRAGMENTS\u003cbr data-mce-fragment=\"1\"\u003eHelp to:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003epromote blood cells adhesion and colonization\u003cbr data-mce-fragment=\"1\"\u003eguarantee a high hydrophilicity thus enhancing the biochemical cascade of signals that promotes the osteoinductive process\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHuman-Like Microstructure\u003cbr data-mce-fragment=\"1\"\u003eThe microstructure of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s composite matrix strongly resembles the human bone in terms of open, interconnected and mid-sized porosity. Indeed, it mimics the characteristics of a healthy human bone: high biocompatibility, adequate open porosity, high mechanical performance, hydrophilicity.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® were designed to reduce the inner variability that many other bone substitutes have, due to their natural origin. IBI offers homogeneous bone substitutes with regular microstructure, porosity, density and mechanical properties.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eExtremely high hydrophilicity and fast osteointegration\u003cbr data-mce-fragment=\"1\"\u003eThanks to its microcomposition, SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® quickly reach an av. 38%w\/w blood swelling ratio, thereby sparking the chemical signaling cascade that finally induces a robust osteointegration.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHigh tissue integration\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s microstructure and composition favor cell colonization.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn Vitro studies\u003cbr data-mce-fragment=\"1\"\u003eThe electronic microscopy analyses of in vitro cell colonization tests evidenced the presence of wide and well-structured cell formations inside SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®, proving confirmation to the biochemical data collected during ISO standard in vitro tests. Biological and histological investigations showed how our bone substitutes are very supportive substrates for cell adhesion and growth; Human adipose-tissue derived Mesenchymal Stem Cells showed in vitro capability to properly colonize the scaffold and, once induced, to differentiate.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn Vivo Studies\u003cbr data-mce-fragment=\"1\"\u003eStudies were performed to assess osteointegration on a 4-month observation timeframe. Histological analysis proved confirmation of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® integration, with natural bone formation, including cells and vessels colonizing pores within it over time.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eDental indications\u003cbr data-mce-fragment=\"1\"\u003eSmartBone® is intended to be used for reconstruction surgeries and for bone regeneration\/augmentation, in the following indications:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eEasy dust free shaping with any type of surgical tool (for example: bone cutter, drill);\u003cbr data-mce-fragment=\"1\"\u003eResistant to heavy loads and to heavy surgical maneuvering;\u003cbr data-mce-fragment=\"1\"\u003eFar better stability of the augmented bone graft vs the loose granules;\u003cbr data-mce-fragment=\"1\"\u003eBigger defects do not need autologous bone, thus reducing patient morbidity;\u003cbr data-mce-fragment=\"1\"\u003eNo resorption: the polymeric coating protects the graft during initial healing\/osteointegration period;\u003cbr data-mce-fragment=\"1\"\u003eReadily absorbs blood.\u003cbr data-mce-fragment=\"1\"\u003eDental indications\u003cbr data-mce-fragment=\"1\"\u003eSmartBone® is intended to be used for reconstruction surgeries and for bone regeneration\/augmentation, in the following indications:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of periodontal bone defects;\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of extraction alveoli;\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of cavities between the alveolar wall and immediate implants;\u003cbr data-mce-fragment=\"1\"\u003eHorizontal alveolar ridge augmentation;\u003cbr data-mce-fragment=\"1\"\u003eSinus lift floor elevation;\u003cbr data-mce-fragment=\"1\"\u003eAlveolar ridge augmentation at implant sites with sufficient residual bone and a good blood supply.\u003c\/p\u003e","brand":"Ibi Sa","offers":[{"title":"0.25 - 1.0 mm","offer_id":41969573625937,"sku":"SMG251020","price":198.0,"currency_code":"USD","in_stock":true},{"title":"1.0 - 2.0 mm","offer_id":41969573658705,"sku":"SMG102020","price":198.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/smartbone2grsite.jpg?v=1734957874"},{"product_id":"ibi-sa-smartbone-bone-regeneration-bone-block-graft-10-10-10-mm","title":"SmartBone Bone Regeneration - Bone Block Graft - 10*10*10 mm","description":"\u003cp\u003e\u003cstrong\u003eSmartBone Bone Regeneration - Bone Block Graft - 10*10*10 mm\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA Bone graft born from Advanced Tissue Engineering Technology\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are produced by combining natural mineral bone structures with bioresorbable polymers and collagen fragments. This new concept of biomaterial assembly allows the patient’s cells to grow quickly and efficiently into the bone substitute while the biopolymers degrade, providing perfect integration and osteogenesis. Moreover, thanks to this technology our graft mimics the human bone, it is mechanically strong and resistant to shaping, screws and surgical fixation maneuvers.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are exactly the same products with just different brand names or different indications of use.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eBOVINE BONE MATRIX\u003cbr data-mce-fragment=\"1\"\u003ehas a chemical structure and a morphology that resemble the human bone\u003cbr data-mce-fragment=\"1\"\u003eis rigid, but not elastic, and thus too fragile (since the mineral matrix loses its biomechanical properties without proteins lost during the cleaning processes)\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eBIODEGRADABLE POLYMERS\u003cbr data-mce-fragment=\"1\"\u003eAllow to have:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003ehigh loading resistance\u003cbr data-mce-fragment=\"1\"\u003ehigh volumetric stability (\u0026gt;95%); the polymers protect the bone from early resorption\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eCOLLAGEN FRAGMENTS\u003cbr data-mce-fragment=\"1\"\u003eHelp to:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003epromote blood cells adhesion and colonization\u003cbr data-mce-fragment=\"1\"\u003eguarantee a high hydrophilicity thus enhancing the biochemical cascade of signals that promotes the osteoinductive process\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHuman-Like Microstructure\u003cbr data-mce-fragment=\"1\"\u003eThe microstructure of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s composite matrix strongly resembles the human bone in terms of open, interconnected and mid-sized porosity. Indeed, it mimics the characteristics of a healthy human bone: high biocompatibility, adequate open porosity, high mechanical performance, hydrophilicity.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® were designed to reduce the inner variability that many other bone substitutes have, due to their natural origin. IBI offers homogeneous bone substitutes with regular microstructure, porosity, density and mechanical properties.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eExtremely high hydrophilicity and fast osteointegration\u003cbr data-mce-fragment=\"1\"\u003eThanks to its microcomposition, SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® quickly reach an av. 38%w\/w blood swelling ratio, thereby sparking the chemical signaling cascade that finally induces a robust osteointegration.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHigh tissue integration\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s microstructure and composition favor cell colonization.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn Vitro studies\u003cbr data-mce-fragment=\"1\"\u003eThe electronic microscopy analyses of in vitro cell colonization tests evidenced the presence of wide and well-structured cell formations inside SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®, proving confirmation to the biochemical data collected during ISO standard in vitro tests. Biological and histological investigations showed how our bone substitutes are very supportive substrates for cell adhesion and growth; Human adipose-tissue derived Mesenchymal Stem Cells showed in vitro capability to properly colonize the scaffold and, once induced, to differentiate.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn Vivo Studies\u003cbr data-mce-fragment=\"1\"\u003eStudies were performed to assess osteointegration on a 4-month observation timeframe. Histological analysis proved confirmation of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® integration, with natural bone formation, including cells and vessels colonizing pores within it over time.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eDental indications\u003cbr data-mce-fragment=\"1\"\u003eSmartBone® is intended to be used for reconstruction surgeries and for bone regeneration\/augmentation, in the following indications:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eEasy dust free shaping with any type of surgical tool (for example: bone cutter, drill);\u003cbr data-mce-fragment=\"1\"\u003eResistant to heavy loads and to heavy surgical maneuvering;\u003cbr data-mce-fragment=\"1\"\u003eFar better stability of the augmented bone graft vs the loose granules;\u003cbr data-mce-fragment=\"1\"\u003eBigger defects do not need autologous bone, thus reducing patient morbidity;\u003cbr data-mce-fragment=\"1\"\u003eNo resorption: the polymeric coating protects the graft during initial healing\/osteointegration period;\u003cbr data-mce-fragment=\"1\"\u003eReadily absorbs blood.\u003cbr data-mce-fragment=\"1\"\u003eDental indications\u003cbr data-mce-fragment=\"1\"\u003eSmartBone® is intended to be used for reconstruction surgeries and for bone regeneration\/augmentation, in the following indications:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of periodontal bone defects;\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of extraction alveoli;\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of cavities between the alveolar wall and immediate implants;\u003cbr data-mce-fragment=\"1\"\u003eHorizontal alveolar ridge augmentation;\u003cbr data-mce-fragment=\"1\"\u003eSinus lift floor elevation;\u003cbr data-mce-fragment=\"1\"\u003eAlveolar ridge augmentation at implant sites with sufficient residual bone and a good blood supply.\u003c\/p\u003e","brand":"Ibi Sa","offers":[{"title":"Default Title","offer_id":41969611964497,"sku":"SMB011010","price":219.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/smartboneblok10x10x10mmsite.jpg?v=1734957408"},{"product_id":"ibi-sa-smartbone-bone-regeneration-bone-block-graft-10-10-20-mm","title":"SmartBone Bone Regeneration - Bone Block Graft - 10*10*20 mm","description":"\u003cp\u003e\u003cstrong\u003eSmartBone Bone Regeneration - Bone Block Graft - 10*10*20 mm\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA Bone graft born from Advanced Tissue Engineering Technology\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are produced by combining natural mineral bone structures with bioresorbable polymers and collagen fragments. This new concept of biomaterial assembly allows the patient’s cells to grow quickly and efficiently into the bone substitute while the biopolymers degrade, providing perfect integration and osteogenesis. Moreover, thanks to this technology our graft mimics the human bone, it is mechanically strong and resistant to shaping, screws and surgical fixation maneuvers.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are exactly the same products with just different brand names or different indications of use.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eBOVINE BONE MATRIX\u003cbr data-mce-fragment=\"1\"\u003ehas a chemical structure and a morphology that resemble the human bone\u003cbr data-mce-fragment=\"1\"\u003eis rigid, but not elastic, and thus too fragile (since the mineral matrix loses its biomechanical properties without proteins lost during the cleaning processes)\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eBIODEGRADABLE POLYMERS\u003cbr data-mce-fragment=\"1\"\u003eAllow to have:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003ehigh loading resistance\u003cbr data-mce-fragment=\"1\"\u003ehigh volumetric stability (\u0026gt;95%); the polymers protect the bone from early resorption\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eCOLLAGEN FRAGMENTS\u003cbr data-mce-fragment=\"1\"\u003eHelp to:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003epromote blood cells adhesion and colonization\u003cbr data-mce-fragment=\"1\"\u003eguarantee a high hydrophilicity thus enhancing the biochemical cascade of signals that promotes the osteoinductive process\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHuman-Like Microstructure\u003cbr data-mce-fragment=\"1\"\u003eThe microstructure of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s composite matrix strongly resembles the human bone in terms of open, interconnected and mid-sized porosity. Indeed, it mimics the characteristics of a healthy human bone: high biocompatibility, adequate open porosity, high mechanical performance, hydrophilicity.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® were designed to reduce the inner variability that many other bone substitutes have, due to their natural origin. IBI offers homogeneous bone substitutes with regular microstructure, porosity, density and mechanical properties.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eExtremely high hydrophilicity and fast osteointegration\u003cbr data-mce-fragment=\"1\"\u003eThanks to its microcomposition, SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® quickly reach an av. 38%w\/w blood swelling ratio, thereby sparking the chemical signaling cascade that finally induces a robust osteointegration.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHigh tissue integration\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s microstructure and composition favor cell colonization.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn Vitro studies\u003cbr data-mce-fragment=\"1\"\u003eThe electronic microscopy analyses of in vitro cell colonization tests evidenced the presence of wide and well-structured cell formations inside SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®, proving confirmation to the biochemical data collected during ISO standard in vitro tests. Biological and histological investigations showed how our bone substitutes are very supportive substrates for cell adhesion and growth; Human adipose-tissue derived Mesenchymal Stem Cells showed in vitro capability to properly colonize the scaffold and, once induced, to differentiate.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn Vivo Studies\u003cbr data-mce-fragment=\"1\"\u003eStudies were performed to assess osteointegration on a 4-month observation timeframe. Histological analysis proved confirmation of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® integration, with natural bone formation, including cells and vessels colonizing pores within it over time.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eDental indications\u003cbr data-mce-fragment=\"1\"\u003eSmartBone® is intended to be used for reconstruction surgeries and for bone regeneration\/augmentation, in the following indications:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eEasy dust free shaping with any type of surgical tool (for example: bone cutter, drill);\u003cbr data-mce-fragment=\"1\"\u003eResistant to heavy loads and to heavy surgical maneuvering;\u003cbr data-mce-fragment=\"1\"\u003eFar better stability of the augmented bone graft vs the loose granules;\u003cbr data-mce-fragment=\"1\"\u003eBigger defects do not need autologous bone, thus reducing patient morbidity;\u003cbr data-mce-fragment=\"1\"\u003eNo resorption: the polymeric coating protects the graft during initial healing\/osteointegration period;\u003cbr data-mce-fragment=\"1\"\u003eReadily absorbs blood.\u003cbr data-mce-fragment=\"1\"\u003eDental indications\u003cbr data-mce-fragment=\"1\"\u003eSmartBone® is intended to be used for reconstruction surgeries and for bone regeneration\/augmentation, in the following indications:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of periodontal bone defects;\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of extraction alveoli;\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of cavities between the alveolar wall and immediate implants;\u003cbr data-mce-fragment=\"1\"\u003eHorizontal alveolar ridge augmentation;\u003cbr data-mce-fragment=\"1\"\u003eSinus lift floor elevation;\u003cbr data-mce-fragment=\"1\"\u003eAlveolar ridge augmentation at implant sites with sufficient residual bone and a good blood supply.\u003c\/p\u003e","brand":"Ibi Sa","offers":[{"title":"Default Title","offer_id":41969665802321,"sku":"SMB011020","price":286.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/smartboneblok10x10x20mmsite.jpg?v=1734957332"},{"product_id":"bionnovation-bonefill-prous-cancellous-bovine-graft-xenograft-0-5gr-0-75-cc","title":"Bonefill Prous (Cancellous) Bovine Graft - Xenograft - 0,5gr (0.75 cc)","description":"\u003cp\u003e\u003cstrong\u003eNATURAL, BOVINE, BONE GRAFTING MATERIAL, IDEAL FOR BONE VOLUME PRESERVATION.\u003c\/strong\u003e\u003cbr\u003eExcellent alternative to autogenous and allogenous bone.\u003cbr\u003eThe mineralized inorganic bone matrix of the Bonefill has a porous macro and micro structure similar to the human cortical and spongy bones. In granulate form, Bonefill Dense, Porous \u0026amp; Mix act as osteoconductive mechanism promoting bone growth and regeneration. With time, the Bonefill is partially remodeled through the action of osteoclasts and osteoblasts, being a viable alternative to autologous bone in defects suitable for its use and indication.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe highly purified osteoconductive mineral structure is produced from natural bone through a multiphase process, complying with the safety regulations established by the control agencies. The fresh bone is crushed, receiving a sequence of baths that solubilize the organic structures such as, for example, remaining cells, fibers and proteins, with only the mineral portion remaining this way in order to avoid the induction of possible immunogenic processes in the body.\u003c\/p\u003e\n\u003cp\u003eThe products made of mineralized bovine bone have an expected incorporation of 6 to 9 months. \u003cbr\u003eHydrophilicity.\u003c\/p\u003e\n\u003cp\u003eThe rapid and complete hydration with blood or saline solution is an important feature of the handling, new bone formation and clinical success. Its strong capillary action allows the rapid and efficient penetration of particles with fluids in the material, nutrients and blood through its three-dimensional network of the trabecular bone, resulting in excellent handling, application and predictability in daily clinical use.\u003cbr\u003eIndications.\u003c\/p\u003e\n\u003cp\u003eBonefill is recommended for filling bone defects and for volumetric increase in the following situations: increase\/reconstructions of alveolar crests, filling of post-extraction cavities, filling of cavities produced by post-surgery treatment interventions of cysts, granulomas and other lytic, oral and maxillofacial and dental pathologies, preparation of implant and filling sites of bone dehiscence, besides bone grafts in maxillary sinuses and in the periodontal area it can be used in filling bone defects and to support the membrane during guided bone regeneration.\u003cbr\u003e. Material Origin: Femoral heads of cattle\u003cbr\u003e. Physicochemical treatment: Chemically treated - Receiving a sequence of baths [3 chemical process steps]\u003cbr\u003e. Appearance Dry state: Whitish up to beige\u003cbr\u003e. Structure Density:  Controlled Inorganic particles of bovine matrix with high macro and micro porosity having a large inner surface area.\u003cbr\u003e. Shelf life: 5 years\u003c\/p\u003e\n\u003cp\u003eCa\/P 1,67\u003cbr\u003eMacroporosity ~65-80%\u003cbr\u003ePore size ~100 – 600 μm\u003cbr\u003e\u003cstrong\u003eIntegration Time estimated 6 - 9 months\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003cfont color=\"#ff0000\"\u003eBonefill Porous [0,10- 0.60 mm] I Large  0,5g = 0,75cc\u003c\/font\u003e\u003cbr\u003e\u003c\/strong\u003eSurface area measured by BET ~77,5 m2\/g\u003cbr\u003eCalcium 27.52%-32.97% w.\/w.\u003cbr\u003ePhosphorous 13.56%-16.28% w.\/w.\u003cbr\u003e\u003cstrong\u003eBonefill Porous = 100% Cancellous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"http:\/\/cdn1.xmlbankasi.com\/p1\/givzltincwmz\/image\/data\/resimler\/bonefill-prous-kemik-grefti-sigir-kaynakli-1-gr-2-cc-661.jpg\"\u003e\u003c\/p\u003e","brand":"Bionnovation","offers":[{"title":"Default Title","offer_id":41969667047505,"sku":"BIO.16911","price":77.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/bonefill-prous-cancellous-bovine-graft-xenograft-05gr-075-cc-379044.jpg?v=1733211615"},{"product_id":"bionnovation-bonefill-prous-cancellous-bovine-graft-xenograft-2-5-gr-5cc","title":"Bonefill Prous (Cancellous) Bovine Graft - Xenograft - 2,5 gr (5cc)","description":"\u003cp\u003e\u003cstrong\u003eNATURAL, BOVINE, BONE GRAFTING MATERIAL, IDEAL FOR BONE VOLUME PRESERVATION.\u003c\/strong\u003e\u003cbr\u003eExcellent alternative to autogenous and allogenous bone.\u003cbr\u003eThe mineralized inorganic bone matrix of the Bonefill has a porous macro and micro structure similar to the human cortical and spongy bones. In granulate form, Bonefill Dense, Porous \u0026amp; Mix act as osteoconductive mechanism promoting bone growth and regeneration. With time, the Bonefill is partially remodeled through the action of osteoclasts and osteoblasts, being a viable alternative to autologous bone in defects suitable for its use and indication.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe highly purified osteoconductive mineral structure is produced from natural bone through a multiphase process, complying with the safety regulations established by the control agencies. The fresh bone is crushed, receiving a sequence of baths that solubilize the organic structures such as, for example, remaining cells, fibers and proteins, with only the mineral portion remaining this way in order to avoid the induction of possible immunogenic processes in the body.\u003c\/p\u003e\n\u003cp\u003eThe products made of mineralized bovine bone have an expected incorporation of 6 to 9 months. \u003cbr\u003eHydrophilicity.\u003c\/p\u003e\n\u003cp\u003eThe rapid and complete hydration with blood or saline solution is an important feature of the handling, new bone formation and clinical success. Its strong capillary action allows the rapid and efficient penetration of particles with fluids in the material, nutrients and blood through its three-dimensional network of the trabecular bone, resulting in excellent handling, application and predictability in daily clinical use.\u003cbr\u003eIndications.\u003c\/p\u003e\n\u003cp\u003eBonefill is recommended for filling bone defects and for volumetric increase in the following situations: increase\/reconstructions of alveolar crests, filling of post-extraction cavities, filling of cavities produced by post-surgery treatment interventions of cysts, granulomas and other lytic, oral and maxillofacial and dental pathologies, preparation of implant and filling sites of bone dehiscence, besides bone grafts in maxillary sinuses and in the periodontal area it can be used in filling bone defects and to support the membrane during guided bone regeneration.\u003cbr\u003e. Material Origin: Femoral heads of cattle\u003cbr\u003e. Physicochemical treatment: Chemically treated - Receiving a sequence of baths [3 chemical process steps]\u003cbr\u003e. Appearance Dry state: Whitish up to beige\u003cbr\u003e. Structure Density:  Controlled Inorganic particles of bovine matrix with high macro and micro porosity having a large inner surface area.\u003cbr\u003e. Shelf life: 5 years\u003c\/p\u003e\n\u003cp\u003eCa\/P 1,67\u003cbr\u003eMacroporosity ~65-80%\u003cbr\u003ePore size ~100 – 600 μm\u003cbr\u003e\u003cstrong\u003eIntegration Time estimated 6 - 9 months\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan color=\"#ff0000\" style=\"color: #ff0000;\"\u003eBonefill Porous [0,60- 1,50 mm] I Large  2,5g = 5cc\u003c\/span\u003e\u003cbr\u003e\u003c\/strong\u003eSurface area measured by BET ~77,5 m2\/g\u003cbr\u003eCalcium 27.52%-32.97% w.\/w.\u003cbr\u003ePhosphorous 13.56%-16.28% w.\/w.\u003cbr\u003e\u003cstrong\u003eBonefill Porous = 100% Cancellous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Bionnovation","offers":[{"title":"Default Title","offer_id":41969676976209,"sku":"BIO.167","price":180.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/bonefill-prous-cancellous-bovine-graft-xenograft-25-gr-5cc-412663.jpg?v=1733145870"},{"product_id":"bionnovation-bonefill-prous-cancellous-bovine-graft-xenograft-1-gr-3cc","title":"Bonefill Prous (Cancellous) Bovine Graft - Xenograft - 1 gr (3cc)","description":"\u003cp\u003e\u003cstrong\u003eNATURAL, BOVINE, BONE GRAFTING MATERIAL, IDEAL FOR BONE VOLUME PRESERVATION.\u003c\/strong\u003e\u003cbr\u003eExcellent alternative to autogenous and allogenous bone.\u003cbr\u003eThe mineralized inorganic bone matrix of the Bonefill has a porous macro and micro structure similar to the human cortical and spongy bones. In granulate form, Bonefill Dense, Porous \u0026amp; Mix act as osteoconductive mechanism promoting bone growth and regeneration. With time, the Bonefill is partially remodeled through the action of osteoclasts and osteoblasts, being a viable alternative to autologous bone in defects suitable for its use and indication.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe highly purified osteoconductive mineral structure is produced from natural bone through a multiphase process, complying with the safety regulations established by the control agencies. The fresh bone is crushed, receiving a sequence of baths that solubilize the organic structures such as, for example, remaining cells, fibers and proteins, with only the mineral portion remaining this way in order to avoid the induction of possible immunogenic processes in the body.\u003c\/p\u003e\n\u003cp\u003eThe products made of mineralized bovine bone have an expected incorporation of 6 to 9 months. \u003cbr\u003eHydrophilicity.\u003c\/p\u003e\n\u003cp\u003eThe rapid and complete hydration with blood or saline solution is an important feature of the handling, new bone formation and clinical success. Its strong capillary action allows the rapid and efficient penetration of particles with fluids in the material, nutrients and blood through its three-dimensional network of the trabecular bone, resulting in excellent handling, application and predictability in daily clinical use.\u003cbr\u003eIndications.\u003c\/p\u003e\n\u003cp\u003eBonefill is recommended for filling bone defects and for volumetric increase in the following situations: increase\/reconstructions of alveolar crests, filling of post-extraction cavities, filling of cavities produced by post-surgery treatment interventions of cysts, granulomas and other lytic, oral and maxillofacial and dental pathologies, preparation of implant and filling sites of bone dehiscence, besides bone grafts in maxillary sinuses and in the periodontal area it can be used in filling bone defects and to support the membrane during guided bone regeneration.\u003cbr\u003e. Material Origin: Femoral heads of cattle\u003cbr\u003e. Physicochemical treatment: Chemically treated - Receiving a sequence of baths [3 chemical process steps]\u003cbr\u003e. Appearance Dry state: Whitish up to beige\u003cbr\u003e. Structure Density:  Controlled Inorganic particles of bovine matrix with high macro and micro porosity having a large inner surface area.\u003cbr\u003e. Shelf life: 5 years\u003c\/p\u003e\n\u003cp\u003eCa\/P 1,67\u003cbr\u003eMacroporosity ~65-80%\u003cbr\u003ePore size ~100 – 600 μm\u003cbr\u003e\u003cstrong\u003eIntegration Time estimated 6 - 9 months\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003cfont color=\"#ff0000\"\u003eBonefill Porous [1,50- 2,50 mm] I Large  1,0g = 3cc\u003c\/font\u003e\u003cbr\u003e\u003c\/strong\u003eSurface area measured by BET ~77,5 m2\/g\u003cbr\u003eCalcium 27.52%-32.97% w.\/w.\u003cbr\u003ePhosphorous 13.56%-16.28% w.\/w.\u003cbr\u003e\u003cstrong\u003eBonefill Porous = 100% Cancellous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"http:\/\/cdn1.xmlbankasi.com\/p1\/givzltincwmz\/image\/data\/resimler\/bonefill-prous-kemik-grefti-sigir-kaynakli-1-gr-2-cc-661.jpg\"\u003e\u003c\/p\u003e","brand":"Bionnovation","offers":[{"title":"Default Title","offer_id":41969677107281,"sku":"BIO.16894","price":55.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/bonefill-prous-cancellous-bovine-graft-xenograft-1-gr-3cc-639769.jpg?v=1783691371"},{"product_id":"bionnovation-bonefill-prous-cancellous-bovine-graft-xenograft-2-5-gr-7cc","title":"Bonefill Prous (Cancellous) Bovine Graft - Xenograft - 2,5 gr (7cc)","description":"\u003cp\u003e\u003cstrong\u003eNATURAL, BOVINE, BONE GRAFTING MATERIAL, IDEAL FOR BONE VOLUME PRESERVATION.\u003c\/strong\u003e\u003cbr\u003eExcellent alternative to autogenous and allogenous bone.\u003cbr\u003eThe mineralized inorganic bone matrix of the Bonefill has a porous macro and micro structure similar to the human cortical and spongy bones. In granulate form, Bonefill Dense, Porous \u0026amp; Mix act as osteoconductive mechanism promoting bone growth and regeneration. With time, the Bonefill is partially remodeled through the action of osteoclasts and osteoblasts, being a viable alternative to autologous bone in defects suitable for its use and indication.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe highly purified osteoconductive mineral structure is produced from natural bone through a multiphase process, complying with the safety regulations established by the control agencies. The fresh bone is crushed, receiving a sequence of baths that solubilize the organic structures such as, for example, remaining cells, fibers and proteins, with only the mineral portion remaining this way in order to avoid the induction of possible immunogenic processes in the body.\u003c\/p\u003e\n\u003cp\u003eThe products made of mineralized bovine bone have an expected incorporation of 6 to 9 months. \u003cbr\u003eHydrophilicity.\u003c\/p\u003e\n\u003cp\u003eThe rapid and complete hydration with blood or saline solution is an important feature of the handling, new bone formation and clinical success. Its strong capillary action allows the rapid and efficient penetration of particles with fluids in the material, nutrients and blood through its three-dimensional network of the trabecular bone, resulting in excellent handling, application and predictability in daily clinical use.\u003cbr\u003eIndications.\u003c\/p\u003e\n\u003cp\u003eBonefill is recommended for filling bone defects and for volumetric increase in the following situations: increase\/reconstructions of alveolar crests, filling of post-extraction cavities, filling of cavities produced by post-surgery treatment interventions of cysts, granulomas and other lytic, oral and maxillofacial and dental pathologies, preparation of implant and filling sites of bone dehiscence, besides bone grafts in maxillary sinuses and in the periodontal area it can be used in filling bone defects and to support the membrane during guided bone regeneration.\u003cbr\u003e. Material Origin: Femoral heads of cattle\u003cbr\u003e. Physicochemical treatment: Chemically treated - Receiving a sequence of baths [3 chemical process steps]\u003cbr\u003e. Appearance Dry state: Whitish up to beige\u003cbr\u003e. Structure Density:  Controlled Inorganic particles of bovine matrix with high macro and micro porosity having a large inner surface area.\u003cbr\u003e. Shelf life: 5 years\u003c\/p\u003e\n\u003cp\u003eCa\/P 1,67\u003cbr\u003eMacroporosity ~65-80%\u003cbr\u003ePore size ~100 – 600 μm\u003cbr\u003e\u003cstrong\u003eIntegration Time estimated 6 - 9 months\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan color=\"#ff0000\" style=\"color: #ff0000;\"\u003eBonefill Porous [1,50- 2,50 mm] I Large  2,5g = 7cc\u003c\/span\u003e\u003cbr\u003e\u003c\/strong\u003eSurface area measured by BET ~77,5 m2\/g\u003cbr\u003eCalcium 27.52%-32.97% w.\/w.\u003cbr\u003ePhosphorous 13.56%-16.28% w.\/w.\u003cbr\u003e\u003cstrong\u003eBonefill Porous = 100% Cancellous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Bionnovation","offers":[{"title":"Default Title","offer_id":41969677172817,"sku":"BIO.16911A","price":70.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/bonefill-prous-cancellous-bovine-graft-xenograft-25-gr-7cc-752585.jpg?v=1733146301"},{"product_id":"ibi-sa-smartbone-bone-regeneration-bone-graft-1gr","title":"SmartBone Bone Regeneration - Bone Graft 1gr","description":"\u003cp\u003e\u003cstrong\u003eSmartBone Bone Regeneration - Bone Graft 1gr\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA Bone graft born from Advanced Tissue Engineering Technology\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are produced by combining natural mineral bone structures with bioresorbable polymers and collagen fragments. This new concept of biomaterial assembly allows the patient’s cells to grow quickly and efficiently into the bone substitute while the biopolymers degrade, providing perfect integration and osteogenesis. Moreover, thanks to this technology our graft mimics the human bone, it is mechanically strong and resistant to shaping, screws and surgical fixation maneuvers.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are exactly the same products with just different brand names or different indications of use.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eBOVINE BONE MATRIX\u003cbr data-mce-fragment=\"1\"\u003ehas a chemical structure and a morphology that resemble the human bone\u003cbr data-mce-fragment=\"1\"\u003eis rigid, but not elastic, and thus too fragile (since the mineral matrix loses its biomechanical properties without proteins lost during the cleaning processes)\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eBIODEGRADABLE POLYMERS\u003cbr data-mce-fragment=\"1\"\u003eAllow to have:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003ehigh loading resistance\u003cbr data-mce-fragment=\"1\"\u003ehigh volumetric stability (\u0026gt;95%); the polymers protect the bone from early resorption\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eCOLLAGEN FRAGMENTS\u003cbr data-mce-fragment=\"1\"\u003eHelp to:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003epromote blood cells adhesion and colonization\u003cbr data-mce-fragment=\"1\"\u003eguarantee a high hydrophilicity thus enhancing the biochemical cascade of signals that promotes the osteoinductive process\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHuman-Like Microstructure\u003cbr data-mce-fragment=\"1\"\u003eThe microstructure of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s composite matrix strongly resembles the human bone in terms of open, interconnected and mid-sized porosity. Indeed, it mimics the characteristics of a healthy human bone: high biocompatibility, adequate open porosity, high mechanical performance, hydrophilicity.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® were designed to reduce the inner variability that many other bone substitutes have, due to their natural origin. IBI offers homogeneous bone substitutes with regular microstructure, porosity, density and mechanical properties.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eExtremely high hydrophilicity and fast osteointegration\u003cbr data-mce-fragment=\"1\"\u003eThanks to its microcomposition, SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® quickly reach an av. 38%w\/w blood swelling ratio, thereby sparking the chemical signaling cascade that finally induces a robust osteointegration.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHigh tissue integration\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s microstructure and composition favor cell colonization.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn Vitro studies\u003cbr data-mce-fragment=\"1\"\u003eThe electronic microscopy analyses of in vitro cell colonization tests evidenced the presence of wide and well-structured cell formations inside SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®, proving confirmation to the biochemical data collected during ISO standard in vitro tests. Biological and histological investigations showed how our bone substitutes are very supportive substrates for cell adhesion and growth; Human adipose-tissue derived Mesenchymal Stem Cells showed in vitro capability to properly colonize the scaffold and, once induced, to differentiate.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn Vivo Studies\u003cbr data-mce-fragment=\"1\"\u003eStudies were performed to assess osteointegration on a 4-month observation timeframe. Histological analysis proved confirmation of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® integration, with natural bone formation, including cells and vessels colonizing pores within it over time.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eDental indications\u003cbr data-mce-fragment=\"1\"\u003eSmartBone® is intended to be used for reconstruction surgeries and for bone regeneration\/augmentation, in the following indications:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eEasy dust free shaping with any type of surgical tool (for example: bone cutter, drill);\u003cbr data-mce-fragment=\"1\"\u003eResistant to heavy loads and to heavy surgical maneuvering;\u003cbr data-mce-fragment=\"1\"\u003eFar better stability of the augmented bone graft vs the loose granules;\u003cbr data-mce-fragment=\"1\"\u003eBigger defects do not need autologous bone, thus reducing patient morbidity;\u003cbr data-mce-fragment=\"1\"\u003eNo resorption: the polymeric coating protects the graft during initial healing\/osteointegration period;\u003cbr data-mce-fragment=\"1\"\u003eReadily absorbs blood.\u003cbr data-mce-fragment=\"1\"\u003eDental indications\u003cbr data-mce-fragment=\"1\"\u003eSmartBone® is intended to be used for reconstruction surgeries and for bone regeneration\/augmentation, in the following indications:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of periodontal bone defects;\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of extraction alveoli;\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of cavities between the alveolar wall and immediate implants;\u003cbr data-mce-fragment=\"1\"\u003eHorizontal alveolar ridge augmentation;\u003cbr data-mce-fragment=\"1\"\u003eSinus lift floor elevation;\u003cbr data-mce-fragment=\"1\"\u003eAlveolar ridge augmentation at implant sites with sufficient residual bone and a good blood supply.\u003c\/p\u003e","brand":"Ibi Sa","offers":[{"title":"0.25 - 1.0 mm","offer_id":41969710334033,"sku":"SMG251010","price":115.0,"currency_code":"USD","in_stock":true},{"title":"1.0 - 2.0 mm","offer_id":41969710366801,"sku":"SMG102010","price":115.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/smartbone1grsite.jpg?v=1734958022"},{"product_id":"bionnovation-bonefill-prous-cancellous-bovine-graft-xenograft-5-gr-10cc","title":"Bonefill Prous (Cancellous) Bovine Graft - Xenograft - 5 gr (10cc)","description":"\u003cp\u003e\u003cstrong\u003eNATURAL, BOVINE, BONE GRAFTING MATERIAL, IDEAL FOR BONE VOLUME PRESERVATION.\u003c\/strong\u003e\u003cbr\u003eExcellent alternative to autogenous and allogenous bone.\u003cbr\u003eThe mineralized inorganic bone matrix of the Bonefill has a porous macro and micro structure similar to the human cortical and spongy bones. In granulate form, Bonefill Dense, Porous \u0026amp; Mix act as osteoconductive mechanism promoting bone growth and regeneration. With time, the Bonefill is partially remodeled through the action of osteoclasts and osteoblasts, being a viable alternative to autologous bone in defects suitable for its use and indication.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe highly purified osteoconductive mineral structure is produced from natural bone through a multiphase process, complying with the safety regulations established by the control agencies. The fresh bone is crushed, receiving a sequence of baths that solubilize the organic structures such as, for example, remaining cells, fibers and proteins, with only the mineral portion remaining this way in order to avoid the induction of possible immunogenic processes in the body.\u003c\/p\u003e\n\u003cp\u003eThe products made of mineralized bovine bone have an expected incorporation of 6 to 9 months. \u003cbr\u003eHydrophilicity.\u003c\/p\u003e\n\u003cp\u003eThe rapid and complete hydration with blood or saline solution is an important feature of the handling, new bone formation and clinical success. Its strong capillary action allows the rapid and efficient penetration of particles with fluids in the material, nutrients and blood through its three-dimensional network of the trabecular bone, resulting in excellent handling, application and predictability in daily clinical use.\u003cbr\u003eIndications.\u003c\/p\u003e\n\u003cp\u003eBonefill is recommended for filling bone defects and for volumetric increase in the following situations: increase\/reconstructions of alveolar crests, filling of post-extraction cavities, filling of cavities produced by post-surgery treatment interventions of cysts, granulomas and other lytic, oral and maxillofacial and dental pathologies, preparation of implant and filling sites of bone dehiscence, besides bone grafts in maxillary sinuses and in the periodontal area it can be used in filling bone defects and to support the membrane during guided bone regeneration.\u003cbr\u003e. Material Origin: Femoral heads of cattle\u003cbr\u003e. Physicochemical treatment: Chemically treated - Receiving a sequence of baths [3 chemical process steps]\u003cbr\u003e. Appearance Dry state: Whitish up to beige\u003cbr\u003e. Structure Density:  Controlled Inorganic particles of bovine matrix with high macro and micro porosity having a large inner surface area.\u003cbr\u003e. Shelf life: 5 years\u003c\/p\u003e\n\u003cp\u003eCa\/P 1,67\u003cbr\u003eMacroporosity ~65-80%\u003cbr\u003ePore size ~100 – 600 μm\u003cbr\u003e\u003cstrong\u003eIntegration Time estimated 6 - 9 months\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eBonefill Porous [0,60- 1,50 mm] I Large  5,0g = 10cc\u003cbr\u003e\u003c\/strong\u003eSurface area measured by BET ~77,5 m2\/g\u003cbr\u003eCalcium 27.52%-32.97% w.\/w.\u003cbr\u003ePhosphorous 13.56%-16.28% w.\/w.\u003cbr\u003e\u003cstrong\u003eBonefill Porous = 100% Cancellous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Bionnovation","offers":[{"title":"Default Title","offer_id":41969758863441,"sku":"BIO.16919A","price":250.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/bonefill-prous-cancellous-bovine-graft-xenograft-5-gr-10cc-272697.jpg?v=1733211616"},{"product_id":"bionnovation-bonefill-prous-cancellous-bovine-graft-xenograft-1-gr-2cc","title":"Bonefill Prous (Cancellous) Bovine Graft - Xenograft - 1 gr (2cc)","description":"\u003cp\u003e\u003cstrong\u003eNATURAL, BOVINE, BONE GRAFTING MATERIAL, IDEAL FOR BONE VOLUME PRESERVATION.\u003c\/strong\u003e\u003cbr\u003eExcellent alternative to autogenous and allogenous bone.\u003cbr\u003eThe mineralized inorganic bone matrix of the Bonefill has a porous macro and micro structure similar to the human cortical and spongy bones. In granulate form, Bonefill Dense, Porous \u0026amp; Mix act as osteoconductive mechanism promoting bone growth and regeneration. With time, the Bonefill is partially remodeled through the action of osteoclasts and osteoblasts, being a viable alternative to autologous bone in defects suitable for its use and indication.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe highly purified osteoconductive mineral structure is produced from natural bone through a multiphase process, complying with the safety regulations established by the control agencies. The fresh bone is crushed, receiving a sequence of baths that solubilize the organic structures such as, for example, remaining cells, fibers and proteins, with only the mineral portion remaining this way in order to avoid the induction of possible immunogenic processes in the body.\u003c\/p\u003e\n\u003cp\u003eThe products made of mineralized bovine bone have an expected incorporation of 6 to 9 months. \u003cbr\u003eHydrophilicity.\u003c\/p\u003e\n\u003cp\u003eThe rapid and complete hydration with blood or saline solution is an important feature of the handling, new bone formation and clinical success. Its strong capillary action allows the rapid and efficient penetration of particles with fluids in the material, nutrients and blood through its three-dimensional network of the trabecular bone, resulting in excellent handling, application and predictability in daily clinical use.\u003cbr\u003eIndications.\u003c\/p\u003e\n\u003cp\u003eBonefill is recommended for filling bone defects and for volumetric increase in the following situations: increase\/reconstructions of alveolar crests, filling of post-extraction cavities, filling of cavities produced by post-surgery treatment interventions of cysts, granulomas and other lytic, oral and maxillofacial and dental pathologies, preparation of implant and filling sites of bone dehiscence, besides bone grafts in maxillary sinuses and in the periodontal area it can be used in filling bone defects and to support the membrane during guided bone regeneration.\u003cbr\u003e. Material Origin: Femoral heads of cattle\u003cbr\u003e. Physicochemical treatment: Chemically treated - Receiving a sequence of baths [3 chemical process steps]\u003cbr\u003e. Appearance Dry state: Whitish up to beige\u003cbr\u003e. Structure Density:  Controlled Inorganic particles of bovine matrix with high macro and micro porosity having a large inner surface area.\u003cbr\u003e. Shelf life: 5 years\u003c\/p\u003e\n\u003cp\u003eCa\/P 1,67\u003cbr\u003eMacroporosity ~65-80%\u003cbr\u003ePore size ~100 – 600 μm\u003cbr\u003e\u003cstrong\u003eIntegration Time estimated 6 - 9 months\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003cfont color=\"#ff0000\"\u003eBonefill Porous [0,60- 1,50 mm] I Large  1,0g = 2cc\u003c\/font\u003e\u003cbr\u003e\u003c\/strong\u003eSurface area measured by BET ~77,5 m2\/g\u003cbr\u003eCalcium 27.52%-32.97% w.\/w.\u003cbr\u003ePhosphorous 13.56%-16.28% w.\/w.\u003cbr\u003e\u003cstrong\u003eBonefill Porous = 100% Cancellous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"http:\/\/cdn1.xmlbankasi.com\/p1\/givzltincwmz\/image\/data\/resimler\/bonefill-prous-kemik-grefti-sigir-kaynakli-1-gr-2-cc-661.jpg\"\u003e\u003c\/p\u003e","brand":"Bionnovation","offers":[{"title":"Default Title","offer_id":41969763287121,"sku":"BIO.16892A","price":110.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/bonefill-prous-cancellous-bovine-graft-xenograft-1-gr-2cc-381426.jpg?v=1733146061"},{"product_id":"bionnovation-bonefill-prous-cancellous-bovine-graft-xenograft-5-gr-15cc","title":"Bonefill Prous (Cancellous) Bovine Graft - Xenograft - 5 gr (15cc)","description":"\u003cp\u003e\u003cstrong\u003eNATURAL, BOVINE, BONE GRAFTING MATERIAL, IDEAL FOR BONE VOLUME PRESERVATION.\u003c\/strong\u003e\u003cbr\u003eExcellent alternative to autogenous and allogenous bone.\u003cbr\u003eThe mineralized inorganic bone matrix of the Bonefill has a porous macro and micro structure similar to the human cortical and spongy bones. In granulate form, Bonefill Dense, Porous \u0026amp; Mix act as osteoconductive mechanism promoting bone growth and regeneration. With time, the Bonefill is partially remodeled through the action of osteoclasts and osteoblasts, being a viable alternative to autologous bone in defects suitable for its use and indication.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe highly purified osteoconductive mineral structure is produced from natural bone through a multiphase process, complying with the safety regulations established by the control agencies. The fresh bone is crushed, receiving a sequence of baths that solubilize the organic structures such as, for example, remaining cells, fibers and proteins, with only the mineral portion remaining this way in order to avoid the induction of possible immunogenic processes in the body.\u003c\/p\u003e\n\u003cp\u003eThe products made of mineralized bovine bone have an expected incorporation of 6 to 9 months. \u003cbr\u003eHydrophilicity.\u003c\/p\u003e\n\u003cp\u003eThe rapid and complete hydration with blood or saline solution is an important feature of the handling, new bone formation and clinical success. Its strong capillary action allows the rapid and efficient penetration of particles with fluids in the material, nutrients and blood through its three-dimensional network of the trabecular bone, resulting in excellent handling, application and predictability in daily clinical use.\u003cbr\u003eIndications.\u003c\/p\u003e\n\u003cp\u003eBonefill is recommended for filling bone defects and for volumetric increase in the following situations: increase\/reconstructions of alveolar crests, filling of post-extraction cavities, filling of cavities produced by post-surgery treatment interventions of cysts, granulomas and other lytic, oral and maxillofacial and dental pathologies, preparation of implant and filling sites of bone dehiscence, besides bone grafts in maxillary sinuses and in the periodontal area it can be used in filling bone defects and to support the membrane during guided bone regeneration.\u003cbr\u003e. Material Origin: Femoral heads of cattle\u003cbr\u003e. Physicochemical treatment: Chemically treated - Receiving a sequence of baths [3 chemical process steps]\u003cbr\u003e. Appearance Dry state: Whitish up to beige\u003cbr\u003e. Structure Density:  Controlled Inorganic particles of bovine matrix with high macro and micro porosity having a large inner surface area.\u003cbr\u003e. Shelf life: 5 years\u003c\/p\u003e\n\u003cp\u003eCa\/P 1,67\u003cbr\u003eMacroporosity ~65-80%\u003cbr\u003ePore size ~100 – 600 μm\u003cbr\u003e\u003cstrong\u003eIntegration Time estimated 6 - 9 months\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eBonefill Porous [1,50- 2,50 mm] I Large  5,0g = 15cc\u003cbr\u003e\u003c\/strong\u003eSurface area measured by BET ~77,5 m2\/g\u003cbr\u003eCalcium 27.52%-32.97% w.\/w.\u003cbr\u003ePhosphorous 13.56%-16.28% w.\/w.\u003cbr\u003e\u003cstrong\u003eBonefill Porous = 100% Cancellous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e","brand":"Bionnovation","offers":[{"title":"Default Title","offer_id":41969764794449,"sku":"BIO.16936A","price":250.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/bonefill-prous-cancellous-bovine-graft-xenograft-5-gr-15cc-537873.jpg?v=1733145869"},{"product_id":"bionnovation-bonefill-prous-cancellous-bovine-graft-xenograft-0-5gr-1cc","title":"Bonefill Prous (Cancellous) Bovine Graft - Xenograft - 0,5gr (1cc)","description":"\u003cp\u003e\u003cstrong\u003eNATURAL, BOVINE, BONE GRAFTING MATERIAL, IDEAL FOR BONE VOLUME PRESERVATION.\u003c\/strong\u003e\u003cbr\u003eExcellent alternative to autogenous and allogenous bone.\u003cbr\u003eThe mineralized inorganic bone matrix of the Bonefill has a porous macro and micro structure similar to the human cortical and spongy bones. In granulate form, Bonefill Dense, Porous \u0026amp; Mix act as osteoconductive mechanism promoting bone growth and regeneration. With time, the Bonefill is partially remodeled through the action of osteoclasts and osteoblasts, being a viable alternative to autologous bone in defects suitable for its use and indication.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThe highly purified osteoconductive mineral structure is produced from natural bone through a multiphase process, complying with the safety regulations established by the control agencies. The fresh bone is crushed, receiving a sequence of baths that solubilize the organic structures such as, for example, remaining cells, fibers and proteins, with only the mineral portion remaining this way in order to avoid the induction of possible immunogenic processes in the body.\u003c\/p\u003e\n\u003cp\u003eThe products made of mineralized bovine bone have an expected incorporation of 6 to 9 months. \u003cbr\u003eHydrophilicity.\u003c\/p\u003e\n\u003cp\u003eThe rapid and complete hydration with blood or saline solution is an important feature of the handling, new bone formation and clinical success. Its strong capillary action allows the rapid and efficient penetration of particles with fluids in the material, nutrients and blood through its three-dimensional network of the trabecular bone, resulting in excellent handling, application and predictability in daily clinical use.\u003cbr\u003eIndications.\u003c\/p\u003e\n\u003cp\u003eBonefill is recommended for filling bone defects and for volumetric increase in the following situations: increase\/reconstructions of alveolar crests, filling of post-extraction cavities, filling of cavities produced by post-surgery treatment interventions of cysts, granulomas and other lytic, oral and maxillofacial and dental pathologies, preparation of implant and filling sites of bone dehiscence, besides bone grafts in maxillary sinuses and in the periodontal area it can be used in filling bone defects and to support the membrane during guided bone regeneration.\u003cbr\u003e. Material Origin: Femoral heads of cattle\u003cbr\u003e. Physicochemical treatment: Chemically treated - Receiving a sequence of baths [3 chemical process steps]\u003cbr\u003e. Appearance Dry state: Whitish up to beige\u003cbr\u003e. Structure Density:  Controlled Inorganic particles of bovine matrix with high macro and micro porosity having a large inner surface area.\u003cbr\u003e. Shelf life: 5 years\u003c\/p\u003e\n\u003cp\u003eCa\/P 1,67\u003cbr\u003eMacroporosity ~65-80%\u003cbr\u003ePore size ~100 – 600 μm\u003cbr\u003e\u003cstrong\u003eIntegration Time estimated 6 - 9 months\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003cfont color=\"#ff0000\"\u003eBonefill Porous [0,60- 1,50 mm] I Large  0,5g = 1cc\u003c\/font\u003e\u003cbr\u003e\u003c\/strong\u003eSurface area measured by BET ~77,5 m2\/g\u003cbr\u003eCalcium 27.52%-32.97% w.\/w.\u003cbr\u003ePhosphorous 13.56%-16.28% w.\/w.\u003cbr\u003e\u003cstrong\u003eBonefill Porous = 100% Cancellous\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"http:\/\/cdn1.xmlbankasi.com\/p1\/givzltincwmz\/image\/data\/resimler\/bonefill-prous-kemik-grefti-sigir-kaynakli-1-gr-2-cc-661.jpg\"\u003e\u003c\/p\u003e","brand":"Bionnovation","offers":[{"title":"Default Title","offer_id":41969764827217,"sku":"BIO.16928","price":77.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/bonefill-prous-cancellous-bovine-graft-xenograft-05gr-1cc-711162.jpg?v=1733145947"},{"product_id":"ibi-sa-smartbone-bone-regeneration-bone-graft-0-5gr","title":"SmartBone Bone Regeneration - Bone Graft 0,5gr","description":"\u003cp\u003e\u003cstrong\u003eSmartBone Bone Regeneration - Bone Graft 0,5gr\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eA Bone graft born from Advanced Tissue Engineering Technology\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are produced by combining natural mineral bone structures with bioresorbable polymers and collagen fragments. This new concept of biomaterial assembly allows the patient’s cells to grow quickly and efficiently into the bone substitute while the biopolymers degrade, providing perfect integration and osteogenesis. Moreover, thanks to this technology our graft mimics the human bone, it is mechanically strong and resistant to shaping, screws and surgical fixation maneuvers.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® are exactly the same products with just different brand names or different indications of use.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eBOVINE BONE MATRIX\u003cbr data-mce-fragment=\"1\"\u003ehas a chemical structure and a morphology that resemble the human bone\u003cbr data-mce-fragment=\"1\"\u003eis rigid, but not elastic, and thus too fragile (since the mineral matrix loses its biomechanical properties without proteins lost during the cleaning processes)\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eBIODEGRADABLE POLYMERS\u003cbr data-mce-fragment=\"1\"\u003eAllow to have:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003ehigh loading resistance\u003cbr data-mce-fragment=\"1\"\u003ehigh volumetric stability (\u0026gt;95%); the polymers protect the bone from early resorption\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eCOLLAGEN FRAGMENTS\u003cbr data-mce-fragment=\"1\"\u003eHelp to:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003epromote blood cells adhesion and colonization\u003cbr data-mce-fragment=\"1\"\u003eguarantee a high hydrophilicity thus enhancing the biochemical cascade of signals that promotes the osteoinductive process\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHuman-Like Microstructure\u003cbr data-mce-fragment=\"1\"\u003eThe microstructure of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s composite matrix strongly resembles the human bone in terms of open, interconnected and mid-sized porosity. Indeed, it mimics the characteristics of a healthy human bone: high biocompatibility, adequate open porosity, high mechanical performance, hydrophilicity.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® were designed to reduce the inner variability that many other bone substitutes have, due to their natural origin. IBI offers homogeneous bone substitutes with regular microstructure, porosity, density and mechanical properties.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eExtremely high hydrophilicity and fast osteointegration\u003cbr data-mce-fragment=\"1\"\u003eThanks to its microcomposition, SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® quickly reach an av. 38%w\/w blood swelling ratio, thereby sparking the chemical signaling cascade that finally induces a robust osteointegration.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eHigh tissue integration\u003cbr data-mce-fragment=\"1\"\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®’s microstructure and composition favor cell colonization.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn Vitro studies\u003cbr data-mce-fragment=\"1\"\u003eThe electronic microscopy analyses of in vitro cell colonization tests evidenced the presence of wide and well-structured cell formations inside SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone®, proving confirmation to the biochemical data collected during ISO standard in vitro tests. Biological and histological investigations showed how our bone substitutes are very supportive substrates for cell adhesion and growth; Human adipose-tissue derived Mesenchymal Stem Cells showed in vitro capability to properly colonize the scaffold and, once induced, to differentiate.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eIn Vivo Studies\u003cbr data-mce-fragment=\"1\"\u003eStudies were performed to assess osteointegration on a 4-month observation timeframe. Histological analysis proved confirmation of SmartBone®, SmartBone® ORTHO, SmartBone® On Demand™ and SwissBone® integration, with natural bone formation, including cells and vessels colonizing pores within it over time.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e \u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eDental indications\u003cbr data-mce-fragment=\"1\"\u003eSmartBone® is intended to be used for reconstruction surgeries and for bone regeneration\/augmentation, in the following indications:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eEasy dust free shaping with any type of surgical tool (for example: bone cutter, drill);\u003cbr data-mce-fragment=\"1\"\u003eResistant to heavy loads and to heavy surgical maneuvering;\u003cbr data-mce-fragment=\"1\"\u003eFar better stability of the augmented bone graft vs the loose granules;\u003cbr data-mce-fragment=\"1\"\u003eBigger defects do not need autologous bone, thus reducing patient morbidity;\u003cbr data-mce-fragment=\"1\"\u003eNo resorption: the polymeric coating protects the graft during initial healing\/osteointegration period;\u003cbr data-mce-fragment=\"1\"\u003eReadily absorbs blood.\u003cbr data-mce-fragment=\"1\"\u003eDental indications\u003cbr data-mce-fragment=\"1\"\u003eSmartBone® is intended to be used for reconstruction surgeries and for bone regeneration\/augmentation, in the following indications:\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of periodontal bone defects;\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of extraction alveoli;\u003cbr data-mce-fragment=\"1\"\u003eRegeneration of cavities between the alveolar wall and immediate implants;\u003cbr data-mce-fragment=\"1\"\u003eHorizontal alveolar ridge augmentation;\u003cbr data-mce-fragment=\"1\"\u003eSinus lift floor elevation;\u003cbr data-mce-fragment=\"1\"\u003eAlveolar ridge augmentation at implant sites with sufficient residual bone and a good blood supply.\u003c\/p\u003e","brand":"Ibi Sa","offers":[{"title":"0.25 - 1.0 mm","offer_id":41969788846161,"sku":"SMG251025","price":78.0,"currency_code":"USD","in_stock":true},{"title":"1.0 - 2.0 mm","offer_id":41969788878929,"sku":"SMG102005","price":78.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/smartbone0.5grsite.jpg?v=1734957755"},{"product_id":"smartbone-block-bone-graft-bovine-sourced-7x7x7-mm","title":"Smartbone Block Bone Graft - Bovine Sourced 7x7x7 mm","description":"\u003cp\u003e\u003cstrong\u003eSmartbone Block Bone Graft - Bovine Sourced 7x7x7 mm\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSmartbone®\u003c\/strong\u003e is a composite bone replacement material composed of a bovine-derived natural mineral matrix reinforced with synthetic, biologically degradable polymers and bovine-derived natural collagen derivatives.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSMARTBONE®\u003c\/strong\u003e possesses a porous macro- and microstructure similar to that found in human bones. The interconnected pores' volume and natural composition facilitate the formation and growth of new bone mass within the implant site. In addition to its high mechanical properties, \u003cstrong\u003eSMARTBONE®\u003c\/strong\u003e offers geometric and volumetric stability. The product does not degrade rapidly and retains its volume significantly, even in cases of inflammation, ensuring minimal volume loss in the implant region.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBenefits and Applications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eRegeneration of periodontal bone defects\u003c\/li\u003e\n\u003cli\u003eRegeneration of extraction sockets\u003c\/li\u003e\n\u003cli\u003eRegeneration of gaps between the alveolar wall and immediate implants\u003c\/li\u003e\n\u003cli\u003eHorizontal alveolar ridge expansion\u003c\/li\u003e\n\u003cli\u003eSinus lift augmentation\u003c\/li\u003e\n\u003cli\u003eAugmentation of the alveolar ridge in implant areas with adequate residual bone and good blood support\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eFeatures:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eEasy and dust-free shaping with all types of surgical tools (e.g., bone cutters, drills)\u003c\/li\u003e\n\u003cli\u003eResistant to heavy loads and intensive surgical maneuvers\u003c\/li\u003e\n\u003cli\u003eEnhanced stability of the bone graft compared to loose granules\u003c\/li\u003e\n\u003cli\u003eNo need for autologous bone in larger defects, reducing patient morbidity\u003c\/li\u003e\n\u003cli\u003eNo resorption: The polymeric coating protects the graft during the initial healing\/osseointegration period\u003c\/li\u003e\n\u003cli\u003eEasily absorbs blood\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eSMARTBONE®\u003c\/strong\u003e offers an advanced solution for various dental and orthopedic procedures, combining exceptional mechanical stability with biocompatibility to support optimal clinical outcomes.\u003c\/p\u003e","brand":"Ibi Sa","offers":[{"title":"Default Title","offer_id":42120277360721,"sku":"SMB011005","price":177.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0601\/1692\/6545\/files\/SmartboneBlok7x7x7mmsite.jpg?v=1783693034"},{"product_id":"smartbone-bone-regeneration-bone-graft-0-25-gr","title":"SmartBone Bone Regeneration - Bone Graft 0.25 gr","description":"\u003cp\u003e\u003cstrong\u003eSmartBone Bone Regeneration - Bone Graft 0.25 gr\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eA Bone Graft Born from Advanced Tissue Engineering Technology\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™, and SwissBone®\u003c\/strong\u003e are produced by combining natural mineral bone structures with biologically degradable polymers and collagen fragments. This innovative biomaterial integration concept allows for excellent integration and osteogenesis by enabling the patient's cells to efficiently replace the bone graft as the biopolymers degrade. Furthermore, thanks to this technology, the graft mimics human bone, is mechanically strong, and is resistant to shaping, screws, and surgical fixation maneuvers.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™, and SwissBone®\u003c\/strong\u003e are essentially the same product with different brand names or intended use indications.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eBovine Bone Matrix\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003ePossesses a chemical composition and morphology similar to human bone.\u003c\/li\u003e\n\u003cli\u003eRigid but not elastic, making it very brittle (due to the loss of biomechanical properties when proteins are removed during the cleaning processes).\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eBiologically Degradable Polymers\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eThese provide:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHigh load resistance.\u003c\/li\u003e\n\u003cli\u003eHigh volumetric stability (more than 95%); polymers protect the bone from premature absorption.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eCollagen Fragments\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eThese support:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromotion of blood cell adhesion and colonization.\u003c\/li\u003e\n\u003cli\u003eGuarantee high hydrophilicity, thereby enhancing the biochemical signaling sequence that supports the osteoinductive process.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eHuman-Like Microstructure\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eThe composite matrix of \u003cstrong\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™, and SwissBone®\u003c\/strong\u003e strongly resembles human bone in its open, interconnected, and medium-sized porosity. It mimics the characteristics of healthy human bone: high biocompatibility, sufficient open porosity, high mechanical performance, and hydrophilicity.\u003c\/p\u003e\n\u003cp\u003eDue to their natural origins, \u003cstrong\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™, and SwissBone®\u003c\/strong\u003e are designed to minimize the intrinsic variability found in other bone substitutes. IBI provides homogeneous bone substitutes with consistent microstructure, porosity, density, and mechanical properties.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eExtremely High Hydrophilicity and Rapid Osseointegration\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eThanks to its microcomposition, \u003cstrong\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™, and SwissBone®\u003c\/strong\u003e rapidly absorb fluids. With a 38% w\/w blood swelling rate, the graft initiates a biochemical signaling cascade that triggers strong osteointegration.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eHigh Tissue Integration\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eThe microstructure and composition of \u003cstrong\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™, and SwissBone®\u003c\/strong\u003e support cell colonization.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eIn Vitro Studies\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eElectron microscopy analyses of in vitro cell colonization tests have demonstrated the presence of extensive and well-structured cell formations within \u003cstrong\u003eSmartBone®, SmartBone® ORTHO, SmartBone® On Demand™, and SwissBone®\u003c\/strong\u003e. These findings validate the biochemical data collected during ISO standard tests. Biological and histological studies confirmed the graft’s suitability as a supportive substrate for cell adhesion and growth. Mesenchymal Stem Cells derived from human adipose tissue showed the ability to properly colonize the scaffold in vitro and differentiate upon stimulation.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eIn Vivo Studies\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eStudies were conducted over a 4-month observation period to evaluate osteointegration. 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